Low bilirubin kernicterus with sepsis and hypoalbuminaemia
نویسندگان
چکیده
منابع مشابه
Unbound bilirubin: a better predictor of kernicterus?
The peroxidase method described in this paper measures non–protein-bound bilirubin by oxidation of the free fraction. The oxidation rate is slow compared with rapid dissociation of albumin-bound bilirubin. Thus, the unbound bilirubin can be estimated from the initial rate of decline in total bilirubin concentration. In the 1970s, severe neonatal hyperbilirubinemia and kernicterus were major cli...
متن کاملStudies in kernicterus. I. The protein binding of bilirubin.
The yellow staining of basal ganglia (kernicterus) in some jaundiced newborn infants has been recognized for many years (1). The association between serum bilirubin concentration and kernicterus (2, 3), the isolation of bilirubin from kernicteric brains (4, 5), and the toxic effect of bilirubin in vitro upon oxygen uptake (6) and oxidative phosphorylation (7) are further evidence of a relations...
متن کاملUrgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus.
Kernicterus, a preventable brain injury resulting from severe neonatal jaundice, has reemerged in the US (1–3). Newborn jaundice, a usually benign condition that typically resolves with supervision and appropriate nutritional intake, can progress to severe hyperbilirubinemia in 8–10% of healthy newborn infants. Severe hyperbilirubinemia may need treatment with phototherapy. Some newborns discha...
متن کاملNeonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency.
We cared for a term male infant born to Burmese immigrants. At about 24 hours a total serum bilirubin (TSB) was 9.3 mg/dL, and phototherapy was begun. It was stopped 48 hours later, with a TSB of 10.9 mg/dL, and he was discharged from the hospital with an appointment for a repeat TSB check 48 hours later. A few hours before the appointment he became listless and apneic, and his parents took him...
متن کاملA Novel Newborn Rat Kernicterus Model Created by Injecting a Bilirubin Solution into the Cisterna Magna
BACKGROUND Kernicterus still occurs around the world; however, the mechanism of bilirubin neurotoxicity remains unclear, and effective treatment strategies are lacking. To solve these problems, several kernicterus (or acute bilirubin encephalopathy) animal models have been established, but these models are difficult and expensive. Therefore, the present study was performed to establish a novel ...
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ژورنال
عنوان ژورنال: Case Reports
سال: 2013
ISSN: 1757-790X
DOI: 10.1136/bcr-2012-008042